ESCLEROSIS MESIAL TEMPORAL PDF

Symptoms[ edit ] This section may be confusing or unclear to readers. In particular, incomplete and confusing sentences. Please help us clarify the section. There might be a discussion about this on the talk page. February Learn how and when to remove this template message Histopathological hallmarks of hippocampal sclerosis include segmental loss of pyramidal neurons , granule cell dispersion and reactive gliosis.

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Gadolinium is not required 5. T2 relaxometry may also be useful in detecting cases of hippocampal sclerosis 5. Diffusion MRI As a result of neuronal loss, the extracellular space is enlarged and thus diffusion of water molecules is greater on the affected side, resulting in increased values on the affected side higher signal on ADC.

Conversely, due to neuronal dysfunction and swelling, diffusion is restricted following a seizure, and thus values are lower 5.

During the peri-ictal phases, perfusion is increased, not only in the mesial temporal lobe but often in large parts of temporal lobe and hemisphere. Treatment and prognosis TLE is initially managed medically with anti-epileptic agents. In patients who are refractory to medical management temporal lobectomy or selective amygdalohippocampectomy may be performed. Shinnar S. Febrile Seizures and Mesial Temporal Sclerosis. Epilepsy Curr. Febrile seizures and mesial temporal sclerosis: No association in a long-term follow-up study.

Neurology full text - Pubmed citation 4. Limbic system abnormalities associated with mesial temporal sclerosis: a model of chronic cerebral changes due to seizures. Radiographics abstract - Pubmed citation 5. Camacho DL, Castillo M. MR imaging of temporal lobe epilepsy. Ultrasound CT MR. Bronen R. MR of mesial temporal sclerosis: how much is enough? MRI evidence of mesial temporal sclerosis in sporadic "benign" temporal lobe epilepsy. Association of magnetic resonance imaging identification of mesial temporal sclerosis with pathological diagnosis and surgical outcomes in children following epilepsy surgery.

J Neurosurg Pediatr. PEDS - Pubmed citation 9. Society of Nuclear Medicine. J Nucl Med. Promoted articles advertising.

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